Hypermineralocorticism

Hyperplasia of the ZG of the adrenal gland(s) or adenoma or carcinoma of the ZG can result in excess production of mineralocorticoid, primarily aldosterone. Clinical signs relate to hypernatremia, plasma volume expansion, and hypokalemia. The condition is rare but should be considered with unexplained persistent hypernatremia and hypokalemia. Aldosterone concentrations can be measured to confirm hypersecretion.